Paul W.S. Anderson's paws have been all over the Resident Evil movie franchise, from writing and directing the 2002 original and the latest sequel, Resident Evil: Afterlife, while writing and producing the woeful 2004 sequel Resident Evil: Apocalypse and the only-slightly better 2007 sequel Resident Evil: Extinction. Anderson's schedule is getting pretty full and it's looking like he's sitting out of Resident Evil 5.
October sees the release of Anderson's Afterlife follow-up, a 3-D adaptation of Alexandre Dumas' The Three Musketeers and, according to THR, Anderson will follow that up with Pompeii, another historical action movie about the 79 A.D. eruption of Italian volcano Mt. Vesuvius.
Pompeii will start shooting next spring, and while Anderson could technically direct Resident Evil 5 after Musketeers opens, no confirmation of a script has been revealed, and squeezing in another movie before Pompeii seems unlikely.
Personally, a fifth sequel with Anderson only producing (I'm speculating here) and someone else writing and directing is really promising. Hopefully, more details about Resident Evil 5 will be revealed soon, though we know it has a release date of September 14, 2012, and Jill Valentine will return.